MyBioSource.com's TOP2A Antibody (C-term) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The TOP2A Antibody (C-term) was generated using TOP2, TOP2A, and Topoisomerase II as the antigen and it reacts with Human.
Description
This gene encodes a DNA topoisomerase, an enzyme that
controls and alters the topologic states of DNA during
transcription. This nuclear enzyme is involved in processes such as
chromosome condensation, chromatid separation, and the relief of
torsional stress that occurs during DNA transcription and
replication. It catalyzes the transient breaking and rejoining of
two strands of duplex DNA which allows the strands to pass through
one another, thus altering the topology of DNA. Two forms of this
enzyme exist as likely products of a gene duplication event. The
gene encoding this form, alpha, is localized to chromosome 17 and
the beta gene is localized to chromosome 3. The gene encoding this
enzyme functions as the target for several anticancer agents and a
variety of mutations in this gene have been associated with the
development of drug resistance. Reduced activity of this enzyme may
also play a role in ataxia-telangiectasia